Exploitation of a novel polysaccharide nanogel cross‐linking membrane for guided bone regeneration (GBR)
Identifieur interne : 003B11 ( Main/Exploration ); précédent : 003B10; suivant : 003B12Exploitation of a novel polysaccharide nanogel cross‐linking membrane for guided bone regeneration (GBR)
Auteurs : Takayuki Miyahara [Japon] ; Myat Nyan [Japon] ; Asako Shimoda [Japon] ; Yuka Yamamoto [Japon] ; Shinji Kuroda [Japon] ; Makoto Shiota [Japon] ; Kazunari Akiyoshi [Japon] ; Shohei Kasugai [Japon]Source :
- Journal of Tissue Engineering and Regenerative Medicine [ 1932-6254 ] ; 2012-08.
Descripteurs français
- Wicri :
- topic : Droit d'auteur.
English descriptors
- KwdEn :
- Acryloyl pullulan, Active molecules, Akiyoshi, Animal experiments, Appl biomater, Augmentation, Barrier membrane, Biochem biophys, Biomed mater, Bone defect, Bone defects, Bone formation, Bone regeneration, Bone trephine burr, Bone volume, Cholesterol groups, Chpoa, Chpoa nanogel solution, Clin, Collagen, Collagen group, Collagen membrane, Collagen membranes, Control group, Copyright, Defect, Defect area, Dental implants, Dental university, Elisa, Elisa assay, Endogenous growth factors, Experimental study, Growth factor, Growth factors, High biocompatibility, Histological images, Horizontal bone augmentation, Hydrogel, Hydrogel nanoparticle, Hydrophobized polysaccharide, Implant, John wiley sons, Maxillofac, Membrane, Membrane groups, Molecular chaperone, Nanogel, Nanogel group, Nanogel membrane, Novel nanogel membrane, Oral implantology, Oral maxillofac implants, Original bone, Osseointegrated titanium implants, Other materials, Partial edentulism, Pdgf, Pdgf concentration, Periodont restor dent, Present study, Previous study, Prospective multicenter study, Prospective study, Pullulan, Radiographical images, Regen, Regeneration, Regenerative, Regenerative site, Regenerative space, Resorbable membranes, Room temperature, Schematic illustration, Signal molecules, Tissue engineering, Tissue regeneration, Wound healing.
- Teeft :
- Acryloyl pullulan, Active molecules, Akiyoshi, Animal experiments, Appl biomater, Augmentation, Barrier membrane, Biochem biophys, Biomed mater, Bone defect, Bone defects, Bone formation, Bone regeneration, Bone trephine burr, Bone volume, Cholesterol groups, Chpoa, Chpoa nanogel solution, Clin, Collagen, Collagen group, Collagen membrane, Collagen membranes, Control group, Copyright, Defect, Defect area, Dental implants, Dental university, Elisa, Elisa assay, Endogenous growth factors, Experimental study, Growth factor, Growth factors, High biocompatibility, Histological images, Horizontal bone augmentation, Hydrogel, Hydrogel nanoparticle, Hydrophobized polysaccharide, Implant, John wiley sons, Maxillofac, Membrane, Membrane groups, Molecular chaperone, Nanogel, Nanogel group, Nanogel membrane, Novel nanogel membrane, Oral implantology, Oral maxillofac implants, Original bone, Osseointegrated titanium implants, Other materials, Partial edentulism, Pdgf, Pdgf concentration, Periodont restor dent, Present study, Previous study, Prospective multicenter study, Prospective study, Pullulan, Radiographical images, Regen, Regeneration, Regenerative, Regenerative site, Regenerative space, Resorbable membranes, Room temperature, Schematic illustration, Signal molecules, Tissue engineering, Tissue regeneration, Wound healing.
Abstract
Cholesterol‐bearing pullulan (CHP) nanogel is a synthetic degradable biomaterial for drug delivery with high biocompatibility. Guided bone regeneration (GBR) is a bone augmentation technique in which a membrane is used to create and keep a secluded regenerative space. The purpose of the present study was to evaluate the effects of the novel CHP nanogel membrane in GBR. Thirty‐six adult Wistar rats were used and bilaterally symmetrical full‐thickness parietal bone defects of 5 mm diameter were created with a bone trephine burr. Each defect was covered with the collagen membrane or the CHP nanogel membrane or untreated without any membrane. The animals were sacrificed at 2, 4 and 8 weeks and analysed radiologically and histologically. Furthermore, after incubating human serum with CHP nanogel or collagen, the amount of PDGF in the serum was measured using ELISA. New bone formation in terms of bone volume was higher in the nanogel group than in the control or collagen groups at 2 and 4 weeks. At 8 weeks, both membrane groups showed higher bone volumes than the control group. Notably, the newly‐formed bone in the bone defect in the nanogel group was uniform and histologically indistinguishable from the original bone, whereas in the collagen group the new bone showed an irregular structure that was completely different from the original bone. After incubating with CHP nanogel, the amount of PDGF in the serum decreased significantly. CHP nanogel GBR membrane favourably stimulated bone regeneration, in which a unique characteristic of CHP nanogel, the storage of endogenous growth factors, was likely implicated. Copyright © 2011 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/term.475
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 004B91
- to stream Istex, to step Curation: 004B91
- to stream Istex, to step Checkpoint: 000F81
- to stream Main, to step Merge: 003B28
- to stream Main, to step Curation: 003B11
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Exploitation of a novel polysaccharide nanogel cross‐linking membrane for guided bone regeneration (GBR)</title><author><name sortKey="Miyahara, Takayuki" sort="Miyahara, Takayuki" uniqKey="Miyahara T" first="Takayuki" last="Miyahara">Takayuki Miyahara</name></author><author><name sortKey="Nyan, Myat" sort="Nyan, Myat" uniqKey="Nyan M" first="Myat" last="Nyan">Myat Nyan</name></author><author><name sortKey="Shimoda, Asako" sort="Shimoda, Asako" uniqKey="Shimoda A" first="Asako" last="Shimoda">Asako Shimoda</name></author><author><name sortKey="Yamamoto, Yuka" sort="Yamamoto, Yuka" uniqKey="Yamamoto Y" first="Yuka" last="Yamamoto">Yuka Yamamoto</name></author><author><name sortKey="Kuroda, Shinji" sort="Kuroda, Shinji" uniqKey="Kuroda S" first="Shinji" last="Kuroda">Shinji Kuroda</name></author><author><name sortKey="Shiota, Makoto" sort="Shiota, Makoto" uniqKey="Shiota M" first="Makoto" last="Shiota">Makoto Shiota</name></author><author><name sortKey="Akiyoshi, Kazunari" sort="Akiyoshi, Kazunari" uniqKey="Akiyoshi K" first="Kazunari" last="Akiyoshi">Kazunari Akiyoshi</name></author><author><name sortKey="Kasugai, Shohei" sort="Kasugai, Shohei" uniqKey="Kasugai S" first="Shohei" last="Kasugai">Shohei Kasugai</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:981DFF74433A3B6CAE1B5B56D676EE6596075952</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1002/term.475</idno><idno type="url">https://api.istex.fr/document/981DFF74433A3B6CAE1B5B56D676EE6596075952/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">004B91</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">004B91</idno><idno type="wicri:Area/Istex/Curation">004B91</idno><idno type="wicri:Area/Istex/Checkpoint">000F81</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000F81</idno><idno type="wicri:doubleKey">1932-6254:2012:Miyahara T:exploitation:of:a</idno><idno type="wicri:Area/Main/Merge">003B28</idno><idno type="wicri:Area/Main/Curation">003B11</idno><idno type="wicri:Area/Main/Exploration">003B11</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Exploitation of a novel polysaccharide nanogel cross‐linking membrane for guided bone regeneration (GBR)</title><author><name sortKey="Miyahara, Takayuki" sort="Miyahara, Takayuki" uniqKey="Miyahara T" first="Takayuki" last="Miyahara">Takayuki Miyahara</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University</wicri:regionArea><wicri:noRegion>Tokyo Medical and Dental University</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Global Centre of Excellence (GCOE) Programme, International Research Centre for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University</wicri:regionArea><wicri:noRegion>Tokyo Medical and Dental University</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Japon</country></affiliation></author><author><name sortKey="Nyan, Myat" sort="Nyan, Myat" uniqKey="Nyan M" first="Myat" last="Nyan">Myat Nyan</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University</wicri:regionArea><wicri:noRegion>Tokyo Medical and Dental University</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Global Centre of Excellence (GCOE) Programme, International Research Centre for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University</wicri:regionArea><wicri:noRegion>Tokyo Medical and Dental University</wicri:noRegion></affiliation></author><author><name sortKey="Shimoda, Asako" sort="Shimoda, Asako" uniqKey="Shimoda A" first="Asako" last="Shimoda">Asako Shimoda</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Organic Biomaterials Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University</wicri:regionArea><wicri:noRegion>Tokyo Medical and Dental University</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Global Centre of Excellence (GCOE) Programme, International Research Centre for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University</wicri:regionArea><wicri:noRegion>Tokyo Medical and Dental University</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Yuka" sort="Yamamoto, Yuka" uniqKey="Yamamoto Y" first="Yuka" last="Yamamoto">Yuka Yamamoto</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Organic Biomaterials Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University</wicri:regionArea><wicri:noRegion>Tokyo Medical and Dental University</wicri:noRegion></affiliation></author><author><name sortKey="Kuroda, Shinji" sort="Kuroda, Shinji" uniqKey="Kuroda S" first="Shinji" last="Kuroda">Shinji Kuroda</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University</wicri:regionArea><wicri:noRegion>Tokyo Medical and Dental University</wicri:noRegion></affiliation></author><author><name sortKey="Shiota, Makoto" sort="Shiota, Makoto" uniqKey="Shiota M" first="Makoto" last="Shiota">Makoto Shiota</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University</wicri:regionArea><wicri:noRegion>Tokyo Medical and Dental University</wicri:noRegion></affiliation></author><author><name sortKey="Akiyoshi, Kazunari" sort="Akiyoshi, Kazunari" uniqKey="Akiyoshi K" first="Kazunari" last="Akiyoshi">Kazunari Akiyoshi</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Organic Biomaterials Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University</wicri:regionArea><wicri:noRegion>Tokyo Medical and Dental University</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University</wicri:regionArea><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName><orgName type="university">Université de Kyoto</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Global Centre of Excellence (GCOE) Programme, International Research Centre for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University</wicri:regionArea><wicri:noRegion>Tokyo Medical and Dental University</wicri:noRegion></affiliation></author><author><name sortKey="Kasugai, Shohei" sort="Kasugai, Shohei" uniqKey="Kasugai S" first="Shohei" last="Kasugai">Shohei Kasugai</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University</wicri:regionArea><wicri:noRegion>Tokyo Medical and Dental University</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Global Centre of Excellence (GCOE) Programme, International Research Centre for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University</wicri:regionArea><wicri:noRegion>Tokyo Medical and Dental University</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Tissue Engineering and Regenerative Medicine</title><title level="j" type="alt">JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE</title><idno type="ISSN">1932-6254</idno><idno type="eISSN">1932-7005</idno><imprint><biblScope unit="vol">6</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="666">666</biblScope><biblScope unit="page" to="672">672</biblScope><biblScope unit="page-count">7</biblScope><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2012-08">2012-08</date></imprint><idno type="ISSN">1932-6254</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1932-6254</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acryloyl pullulan</term><term>Active molecules</term><term>Akiyoshi</term><term>Animal experiments</term><term>Appl biomater</term><term>Augmentation</term><term>Barrier membrane</term><term>Biochem biophys</term><term>Biomed mater</term><term>Bone defect</term><term>Bone defects</term><term>Bone formation</term><term>Bone regeneration</term><term>Bone trephine burr</term><term>Bone volume</term><term>Cholesterol groups</term><term>Chpoa</term><term>Chpoa nanogel solution</term><term>Clin</term><term>Collagen</term><term>Collagen group</term><term>Collagen membrane</term><term>Collagen membranes</term><term>Control group</term><term>Copyright</term><term>Defect</term><term>Defect area</term><term>Dental implants</term><term>Dental university</term><term>Elisa</term><term>Elisa assay</term><term>Endogenous growth factors</term><term>Experimental study</term><term>Growth factor</term><term>Growth factors</term><term>High biocompatibility</term><term>Histological images</term><term>Horizontal bone augmentation</term><term>Hydrogel</term><term>Hydrogel nanoparticle</term><term>Hydrophobized polysaccharide</term><term>Implant</term><term>John wiley sons</term><term>Maxillofac</term><term>Membrane</term><term>Membrane groups</term><term>Molecular chaperone</term><term>Nanogel</term><term>Nanogel group</term><term>Nanogel membrane</term><term>Novel nanogel membrane</term><term>Oral implantology</term><term>Oral maxillofac implants</term><term>Original bone</term><term>Osseointegrated titanium implants</term><term>Other materials</term><term>Partial edentulism</term><term>Pdgf</term><term>Pdgf concentration</term><term>Periodont restor dent</term><term>Present study</term><term>Previous study</term><term>Prospective multicenter study</term><term>Prospective study</term><term>Pullulan</term><term>Radiographical images</term><term>Regen</term><term>Regeneration</term><term>Regenerative</term><term>Regenerative site</term><term>Regenerative space</term><term>Resorbable membranes</term><term>Room temperature</term><term>Schematic illustration</term><term>Signal molecules</term><term>Tissue engineering</term><term>Tissue regeneration</term><term>Wound healing</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acryloyl pullulan</term><term>Active molecules</term><term>Akiyoshi</term><term>Animal experiments</term><term>Appl biomater</term><term>Augmentation</term><term>Barrier membrane</term><term>Biochem biophys</term><term>Biomed mater</term><term>Bone defect</term><term>Bone defects</term><term>Bone formation</term><term>Bone regeneration</term><term>Bone trephine burr</term><term>Bone volume</term><term>Cholesterol groups</term><term>Chpoa</term><term>Chpoa nanogel solution</term><term>Clin</term><term>Collagen</term><term>Collagen group</term><term>Collagen membrane</term><term>Collagen membranes</term><term>Control group</term><term>Copyright</term><term>Defect</term><term>Defect area</term><term>Dental implants</term><term>Dental university</term><term>Elisa</term><term>Elisa assay</term><term>Endogenous growth factors</term><term>Experimental study</term><term>Growth factor</term><term>Growth factors</term><term>High biocompatibility</term><term>Histological images</term><term>Horizontal bone augmentation</term><term>Hydrogel</term><term>Hydrogel nanoparticle</term><term>Hydrophobized polysaccharide</term><term>Implant</term><term>John wiley sons</term><term>Maxillofac</term><term>Membrane</term><term>Membrane groups</term><term>Molecular chaperone</term><term>Nanogel</term><term>Nanogel group</term><term>Nanogel membrane</term><term>Novel nanogel membrane</term><term>Oral implantology</term><term>Oral maxillofac implants</term><term>Original bone</term><term>Osseointegrated titanium implants</term><term>Other materials</term><term>Partial edentulism</term><term>Pdgf</term><term>Pdgf concentration</term><term>Periodont restor dent</term><term>Present study</term><term>Previous study</term><term>Prospective multicenter study</term><term>Prospective study</term><term>Pullulan</term><term>Radiographical images</term><term>Regen</term><term>Regeneration</term><term>Regenerative</term><term>Regenerative site</term><term>Regenerative space</term><term>Resorbable membranes</term><term>Room temperature</term><term>Schematic illustration</term><term>Signal molecules</term><term>Tissue engineering</term><term>Tissue regeneration</term><term>Wound healing</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Droit d'auteur</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Cholesterol‐bearing pullulan (CHP) nanogel is a synthetic degradable biomaterial for drug delivery with high biocompatibility. Guided bone regeneration (GBR) is a bone augmentation technique in which a membrane is used to create and keep a secluded regenerative space. The purpose of the present study was to evaluate the effects of the novel CHP nanogel membrane in GBR. Thirty‐six adult Wistar rats were used and bilaterally symmetrical full‐thickness parietal bone defects of 5 mm diameter were created with a bone trephine burr. Each defect was covered with the collagen membrane or the CHP nanogel membrane or untreated without any membrane. The animals were sacrificed at 2, 4 and 8 weeks and analysed radiologically and histologically. Furthermore, after incubating human serum with CHP nanogel or collagen, the amount of PDGF in the serum was measured using ELISA. New bone formation in terms of bone volume was higher in the nanogel group than in the control or collagen groups at 2 and 4 weeks. At 8 weeks, both membrane groups showed higher bone volumes than the control group. Notably, the newly‐formed bone in the bone defect in the nanogel group was uniform and histologically indistinguishable from the original bone, whereas in the collagen group the new bone showed an irregular structure that was completely different from the original bone. After incubating with CHP nanogel, the amount of PDGF in the serum decreased significantly. CHP nanogel GBR membrane favourably stimulated bone regeneration, in which a unique characteristic of CHP nanogel, the storage of endogenous growth factors, was likely implicated. Copyright © 2011 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région du Kansai</li></region><settlement><li>Kyoto</li></settlement><orgName><li>Université de Kyoto</li></orgName></list><tree><country name="Japon"><noRegion><name sortKey="Miyahara, Takayuki" sort="Miyahara, Takayuki" uniqKey="Miyahara T" first="Takayuki" last="Miyahara">Takayuki Miyahara</name></noRegion><name sortKey="Akiyoshi, Kazunari" sort="Akiyoshi, Kazunari" uniqKey="Akiyoshi K" first="Kazunari" last="Akiyoshi">Kazunari Akiyoshi</name><name sortKey="Akiyoshi, Kazunari" sort="Akiyoshi, Kazunari" uniqKey="Akiyoshi K" first="Kazunari" last="Akiyoshi">Kazunari Akiyoshi</name><name sortKey="Akiyoshi, Kazunari" sort="Akiyoshi, Kazunari" uniqKey="Akiyoshi K" first="Kazunari" last="Akiyoshi">Kazunari Akiyoshi</name><name sortKey="Kasugai, Shohei" sort="Kasugai, Shohei" uniqKey="Kasugai S" first="Shohei" last="Kasugai">Shohei Kasugai</name><name sortKey="Kasugai, Shohei" sort="Kasugai, Shohei" uniqKey="Kasugai S" first="Shohei" last="Kasugai">Shohei Kasugai</name><name sortKey="Kuroda, Shinji" sort="Kuroda, Shinji" uniqKey="Kuroda S" first="Shinji" last="Kuroda">Shinji Kuroda</name><name sortKey="Miyahara, Takayuki" sort="Miyahara, Takayuki" uniqKey="Miyahara T" first="Takayuki" last="Miyahara">Takayuki Miyahara</name><name sortKey="Miyahara, Takayuki" sort="Miyahara, Takayuki" uniqKey="Miyahara T" first="Takayuki" last="Miyahara">Takayuki Miyahara</name><name sortKey="Nyan, Myat" sort="Nyan, Myat" uniqKey="Nyan M" first="Myat" last="Nyan">Myat Nyan</name><name sortKey="Nyan, Myat" sort="Nyan, Myat" uniqKey="Nyan M" first="Myat" last="Nyan">Myat Nyan</name><name sortKey="Shimoda, Asako" sort="Shimoda, Asako" uniqKey="Shimoda A" first="Asako" last="Shimoda">Asako Shimoda</name><name sortKey="Shimoda, Asako" sort="Shimoda, Asako" uniqKey="Shimoda A" first="Asako" last="Shimoda">Asako Shimoda</name><name sortKey="Shiota, Makoto" sort="Shiota, Makoto" uniqKey="Shiota M" first="Makoto" last="Shiota">Makoto Shiota</name><name sortKey="Yamamoto, Yuka" sort="Yamamoto, Yuka" uniqKey="Yamamoto Y" first="Yuka" last="Yamamoto">Yuka Yamamoto</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003B11 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003B11 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:981DFF74433A3B6CAE1B5B56D676EE6596075952
|texte= Exploitation of a novel polysaccharide nanogel cross‐linking membrane for guided bone regeneration (GBR)
}}
| This area was generated with Dilib version V0.6.32. |  |